Conditions Associated With Severe Spasticity
Spasticity can be the initial manifestation of several different neurological illnesses or be due to worsening of a long-term neurological condition.1
Severe spasticity commonly affects people who have had prior nerve damage or neurological conditions, such as those afflicted by: 1
-
Brain injury
-
Cerebral palsy
-
Multiple sclerosis (MS)
-
Spinal cord injury
-
Stroke
![from signs of page to SCI page](https://lioresal.com/wp-content/uploads/2017/05/from-signs-of-page-to-SCI-page.jpg)
It is important to recognize that spasticity can occur alongside these and other neurological conditions, or may even appear long after the original injury or trigger event. For example, while about ¼ of patients with stroke demonstrate signs of spasticity within 6 weeks, spasticity may not occur in some victims of stroke until a year after the stroke occurred. On the other hand, patients with MS may experience more or worsening symptoms, including spasticity, as their diseases progresses over time.1-6
Serious adverse events have been reported with Lioresal® Intrathecal (baclofen injection) use, including seizures during overdose and with withdrawal from Lioresal® Intrathecal as well as in patients maintained on therapeutic doses of Lioresal® Intrathecal. Fatalities have been reported with Lioresal® Intrathecal use.
Who may be affected by Severe Spasticity?
![](https://lioresal.com/wp-content/uploads/2017/05/6percent.png)
~100,000 brain
injury patients7
![](https://lioresal.com/wp-content/uploads/2017/05/50percent.png)
50% of patients
with cerebral palsy7
![](https://lioresal.com/wp-content/uploads/2017/05/38percent.png)
38% of MS
patients7
![](https://lioresal.com/wp-content/uploads/2017/05/33percent.png)
33% of spinal
cord injury patients7
![](https://lioresal.com/wp-content/uploads/2017/05/30percent.png)
30% of stroke
patients7
Learn more about severe spasticity in patients with specific neurologic conditions by clicking here.
- Nair KP, Marsden J. The management of spasticity in adults. BMJ. 2014;349:g4737.
- Opheim A, Danielsson A, Alt Murphy M, Persson HC, Sunnerhagen KS. Early prediction of long-term upper limb spasticity after stroke: part of the SALGOT study. Neurology. 2015;85(10):873-880.
- Lundstrom E, Smits A, Terent A, Borg J. Time-course and determinants of spasticity during the first six months following first-ever stroke. J Rehabil Med. 2010;42(4):296-301.
- Kwah LK, Harvey LA, Diong JH, et al. Half of the adults who present to hospital with stroke develop at least one contracture within six months: an observational study. J Physiother. 2012;58(1):41-47.
- Wissel J, Schelosky LD, Scott J et al. Early development of spasticity following stroke: a prospective, observational trial. J Neurol. 2010;257(7):1067-1072.
- Lundstrom E, Terent A, Borg J. Prevalence of disabling spasticity 1 year after first-ever stroke. Eur J Neurol. 2008;15(6):533-539.
- McGuire JR. Chapter 2: Epidemiology of spasticity in the adult and child. In: Brashear A, Elovic E, eds. Spasticity: Diagnosis and Management. 2nd ed. New York, NY: Demos Medical Publishing, LLC, 2016.