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Living with spasticity can be challenging for your patients and their families and caregivers. The impact of severe spasticity can affect both the patient and their caregiver physically, mentally, emotionally, and socially.1

Conversely, a patient’s severe spasticity can also be affected by many factors. These can include temperature, time of day, emotional status, and body position.2

Treating spasticity can be a long process involving many different providers, each with their own roles in the treatment big picture. Treatments are also

varied and include physical therapies, such as exercise and stretching, and medication, such as oral baclofen, Lioresal® Intrathecal (baclofen injection), and botulinum toxin. Each treatment has its place in patient management, but there is no treatment that offers a cure for spasticity.3

Your patients are not alone in experiencing severe spasticity, and there are resources available for education and to help patients and caregivers cope with the condition. In addition to the resources listed here, many healthcare providers have their own local support groups providing resources closer to your patients’ homes. 3

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Learn More About Severe Spasticity

Learn More About ITB Therapy℠ With Lioresal® Intrathecal

Lioresal® Intrathecal (baclofen injection) is a muscle relaxant and antispastic that is indicated for use in the management of severe spasticity of cerebral or spinal origin. Lioresal® Intrathecal via an implantable pump should be reserved for patients unresponsive to oral baclofen therapy or those who experience intolerable CNS side effects at effective doses. Patients with spasticity due to traumatic brain injury should wait at least one year after the injury before consideration of long term intrathecal baclofen therapy. Lioresal® Intrathecal is contraindicated in patients with hypersensitivity to baclofen. Safety and effectiveness in pediatric patients below the age of 4 have not been established.

 

  1. Nair KP, Marsden J. The management of spasticity in adults. BMJ. 2014;349:g4737.
  2. Boster AL, Bennett SE, Bilsky GS, et al. Best practices for intrathecal baclofen therapy: screening test. Neuromodulation. 2016;19(6):616-622.
  3. Spasticity. National Multiple Sclerosis Society website. https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Spasticity. Accessed February 22, 2017.

Important Safety Information for Lioresal® Intrathecal (baclofen injection)

Abrupt discontinuation of intrathecal baclofen, regardless of the cause, has resulted in sequelae that include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, that in rare cases has advanced to rhabdomyolysis, multiple organ-system failure and death.

Prevention of abrupt discontinuation of intrathecal baclofen requires careful attention to programming and monitoring of the infusion system, refill scheduling and procedures, and pump alarms. Patients and caregivers should be advised of the importance of keeping scheduled refill visits and should be educated on the early symptoms of baclofen withdrawal. Special attention should be given to patients at apparent risk (e.g. spinal cord injuries at T-6 or above, communication difficulties, history of withdrawal symptoms from oral or intrathecal baclofen). Consult the technical manual of the implantable infusion system for additional postimplant clinician and patient information (see WARNINGS).

Indications and Usage

Contraindications

Select Warnings and Precautions

Adverse Reactions

Common Adverse Reactions

Serious Adverse Reactions

Postmarketing Experience

Use in Specific Populations

For more information, including BOXED WARNING, refer to Lioresal® Intrathecal (baclofen injection) prescribing information.